Design and rationale of “a pragmatic approach to the investigation of stable chest pain: A UK, multicenter, randomized trial to assess patient outcomes, quality of life and cost effectiveness (CE-MARC 3)”
Study context
- Population
- Patients newly referred for investigation of suspected cardiac chest pain, about 20 UK sitesplanned
- Participants
- 4,000 patients
- Planned comparison
- Personalized investigation strategy vs Computed Tomography Coronary Angiography (CTCA) first-line for allcomers
- Primary endpoint
- Time to composite of:
- CV death
- MI
- Unobstructed coronary arteries on invasive angiography
Methodological detailsmulticentre, pragmatic, 1:1 randomisation, about 20 UK sites, remote trial pathway option, Cost-effectiveness analysis (quality adjusted life years (QALYs) by EQ-5D-5L), Follow-up at 6 and 12 months, then annually for up to 4 years, First site opened April 2022; recruitment due to complete by July 2025
- Multicentre
- Pragmatic
- 1:1 randomisation
- About 20 UK sites
- Remote trial pathway option
- Cost-effectiveness analysis (QALYs by EQ-5D-5L)
- Follow-up at 6 and 12 months, then annually for up to 4 years
- First site opened April 2022; recruitment due to complete by July 2025
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Design and rationale of “a pragmatic approach to the investigation of stable chest pain: A UK, multicenter, randomized trial to assess patient outcomes, quality of life and cost effectiveness (CE-MARC 3)”. Am Heart J. Published 15 May 2025. doi:10.
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