Coronary disease & ACS

Re-engineering the clinical approach to suspected cardiac chest pain assessment in the emergency department by expediting research evidence to practice using artificial intelligence. (RAPIDx artificial intelligence (AI))—a cluster randomized study design

Am Heart JPublished prospective, multicenter, open-label, cluster-randomized clinical trial within blinded endpoint adjudication

Study context

Population
Patients presenting to EDs with suspected cardiac chest painplanned enrolment across 12 hospitals
Participants
20,000 patients
Planned comparison
Clinical decision-support tool vs current standard of care
Primary endpoint
Composite of:
  • Cardiovascular mortality
  • New or recurrent MI and unplanned hospital re-admission
Follow-up
12 months post index presentation
Methodological details12 hospitals, study design (protocol); no results reported
  • 12 hospitals
  • Study design (protocol); no results reported

No results yet. This paper sets out the design of a trial; its results are to come.

Original publication

Re-engineering the clinical approach to suspected cardiac chest pain assessment in the emergency department by expediting research evidence to practice using artificial intelligence. (RAPIDx AI)—a cluster randomized study design. Am Heart J. Published 22 February 2025. doi:10.1016/j.ahj.2025.02.016

Summarised from the published abstract; every number is checked against it

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