Valvular & structural heart disease
Determinants of adverse outcomes following patent foramen ovale closure in elderly patients
Authors' conclusion
Older patients undergoing PFO closure had a relatively low rate of CVE and new-onset AF after a median follow-up of 2 years. The presence of diabetes, ASA, and a more advanced age determined an increased risk of adverse clinical events.
Study context
- Population
- Patients over 60 years undergoing patent foramen ovale (PFO) closure for cryptogenic thromboembolic events
- Participants
- 689 participants
- Outcome
- Incidence and predictors of adverse events (recurrent cerebrovascular events [CVE] and AF) post-PFO closure
- Follow-up
- Median 2 (IQR 1-5) years
Methodological detailsCompeting risk and adjusted outcome predictor analyses
- Competing risk and adjusted outcome predictor analyses
Main finding
As reported in the abstract
Incidence and predictors of CVE and new-onset AF
Estimate (95% CI)P value
DiabetesCVE risk
HR 3.89(1.67–9.07)
P = 0.002ASACVE risk
HR 5.25(1.56–17.62)
P = 0.007Older ageAF risk
HR 1.05 per year(1.00–1.09)
P = 0.023Absence of hypertensionAF risk
HR 2.04(1.19–3.57)
P = 0.010Per year, as printed
- CVE rate
- 1.21 per 100 patient-years
- Stroke rate
- 0.55 per 100 patient-years
- New-onset AF rate
- 3.30 per 100 patient-years
- New-onset AF within one month post-procedure
- 51.3%
Observational data: associations, not effects.
Further findings
Procedural success
- Procedural success rate
- 99.4%
Death · median follow-up 2 (IQR 1-5) years
- Patients who died
- 66 (9.6%)
Original publication
Determinants of adverse outcomes following patent foramen ovale closure in elderly patients. EuroIntervention. Published 19 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →