Valvular & structural heart disease
Determinants of Tricuspid Regurgitation Progression and Its Implications for Adequate Management
Authors' conclusion
Marked individual variability in TR progression hindered accurate follow-up. In addition, TR progression was a determinant for survival regardless of initial TR severity.
Study context
- Population
- Patients with at least moderate tricuspid regurgitation (TR) followed ≥2 years
- Participants
- 1,843 patients
- Outcome
- Predictors of TR progression and prognostic impact of TR progression
Main finding
As reported in the abstract
TR progression · median 2.3-year follow-up
- Patients with TR progression
- 19%
- Progression rate, baseline moderate TR, 1 year
- 4.9%
- Progression rate, baseline moderate TR, 2 years
- 10.1%
- Progression rate, baseline moderate TR, 3 years
- 24.8%
- Older age, independently associated (HR)
- 1.03
- Lower BMI, independently associated (HR)
- 0.95
- CKD, independently associated (HR)
- 1.55
- Worse NYHA functional class, independently associated (HR)
- 1.52
- RV dilation, independently associated (HR)
- 1.33
- TR progression associated with increased CV mortality and HF hospitalizations
- P < 0.001
Observational data: associations, not effects.
Further findings
- TR progression associated with increased chamber dilation and decreased ventriculoarterial coupling and LVEF
- P < 0.001
Original publication
Determinants of Tricuspid Regurgitation Progression and Its Implications for Adequate Management. JACC Cardiovasc Imaging. Published 6 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →