Valvular & structural heart disease
Right Heart Remodeling and Outcomes in Patients With Tricuspid Regurgitation: A Literature Review and Meta-Analysis
Authors' conclusion
RV dysfunction parameters are associated to worse clinical outcomes in patients with TR, whereas right atrial dilatation is linked to a better prognostic outcome.
Study context
- Population
- Patients with significant tricuspid regurgitation (TR) (at least moderate, ≥2+)
- Participants
- 4,394 patients14 studies
- Outcome
- Long-term (>1 year) all-cause mortality and its association with right heart remodeling
- Follow-up
- >1 year
Methodological detailsmeta-regression, PRISMA
- Meta-regression
- PRISMA
Pooled result
As reported in the abstract
TAPSE (11 studies, 3,551 subjects): inverse relation with mortality, 95% CI −11.1% to −1.4%, P = 0.011
−6.3%
Right ventricular (RV) fractional area change (9 studies, 2,975 subjects): inverse relation with mortality, 95% CI −5.9% to −2.9%, P < 0.001
−4.4%
Tricuspid annular dimension (7 studies, 2,986 subjects): inverse relation with mortality, 95% CI −7.6% to −0.5%, P = 0.026
−4.1%
Right atrial area (6 studies, 1,920 subjects): inverse relation with mortality, 95% CI −2.5% to −1.3%, P < 0.001
−1.9%
Further pooled results
Overall long-term all-cause mortality · follow-up 15.5 to 73.2 months
- Pooled all-cause mortality
- 31% (95% CI: 20%-41%; P ≤ 0.001)
Original publication
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