Coronary disease & ACSCohort study
Development and validation of the INFLammation in Acute Myocardial diseases risk Estimation for Myocardial Infarction (INFLAME-MI) score
- Retrospective cohort study
- multicentre
- external validation
Authors' conclusion
In external validation, it demonstrates comparable discrimination, improved calibration, and higher net benefit at ≤7% thresholds compared with the GRACE score, particularly within key decision-making ranges.
Study context
- Population
- Consecutive patients presenting with acute MI, 2016–2023derivation 3028
- Exposure
- INFLAME-MI score vs Global Registry of Acute Coronary Events (GRACE) score
- Outcome
- In-hospital mortality
Main finding
In-hospital mortality (external validation)
AUC
0.92
P = 0.256
By group
INFLAME-MI
6.2 (P = 0.102)
Hosmer-Lemeshow χ²₈
GRACE
22.9 (P < 0.001)
Hosmer-Lemeshow χ²₈
As reported in the abstract
Observational data: associations, not effects.
Further findings
In-hospital mortality, internal discrimination (derivation cohort)
- Internal discrimination, AUC
- 0.88
- derivation cohort n = 3028
Original publication
Development and validation of the INFLammation in Acute Myocardial diseases risk Estimation for Myocardial Infarction (INFLAME-MI) score. Eur J Prev Cardiol. Published 20 January 2026. doi:10.1093/eurjpc/zwag035
Summarised from the published abstract; every number is checked against it