Arrhythmias & electrophysiology
Development and validation of a new disease-specific quality-of-life measure for atrial fibrillation derived from patient perspectives: The Atrial Fibrillation Patient-Reported Outcome Measures (AF-PROMs) Questionnaire
An erratum to this article was published (Heart Rhythm, May 2026 ↗)
Authors' conclusion
AF-PROMs is a validated, patient-centered instrument, developed with the largest participant group to date, offering a comprehensive assessment of HRQoL in patients with AF. Its unique strengths include extensive patient involvement, high reliability, and sensitivity to clinical interventions, making it a valuable tool for both clinical practice and research in enhancing the measurement of HRQoL in AF.
Study context
- Population
- Patients with atrial fibrillation (AF), with healthy volunteers for known-group validityparticipants enrolled · pilot phase 265 · field-validation phase 550
- Participants
- 856 patients
- Exposure
- Known-group validity: healthy volunteers vs patients with AF
- Outcome
- Internal consistency across all domains
Methodological details2 centers in the United Kingdom
- 2 centers in the United Kingdom
Main finding
As reported in the abstract
Cronbach's alpha
≥0.89
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Known-group validity, all domainsSignificant across all domains | P < 0.01 |
Test-retest reliability
- Intraclass correlation coefficient [ICC]
- >0.97
Responsiveness to clinical changes, particularly post-catheter ablation
- Cohen's d for overall score
- ≥1.0
- Moderate to large effect sizes
3-factor model fit
- The 3-factor model achieved a satisfactory fit
Original publication
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