Device-Removal, Reinfection, and Mortality After Staphylococcus aureus Bacteremia in Patients With Cardiac Implantable Electronic Devices
Main finding · All-cause mortalityResult — go to the resultAdjusted hazard ratio 1.11 95% CI 1.02–1.22Authors' conclusion
The Danish CIED carriers had slightly higher 30-day all-cause mortality after SAB compared to matched controls. Only a minor selected proportion underwent device removal after SAB diagnosis and, after initial survival, these patients had lower 180-days reinfection rates and mortality compared to patients with retained devices.
Study context
- Population
- Patients with Staphylococcus aureus bacteremia (SAB) after cardiac implantable electronic device (CIED) implantation in Denmark between 2000 and 2020patients with CIED and SAB, plus 9,080 matched controls · patients with CIED and SAB 1,816 · matched controls 9,080
- Participants
- 1,816 patients
- Exposure
- Patients with CIED vs controls
- Patients with CIEDn = 1,816
- Controlsn = 9,080reference
- Outcome
- All-cause mortality
- Follow-up
- 30 days
Methodological detailssex and age-matched non-CIED controls with SAB, landmark analysis at the time of hospital discharge
- Sex and age-matched non-CIED controls with SAB
- Landmark analysis at the time of hospital discharge
Main finding
As reported in the abstract
Adjusted hazard ratio
1.11
95% CI 1.02–1.22
P = 0.019
By group
Patients with CIED vs controls
adjusted HR 1.11 (95% CI 1.02–1.22); P = 0.019
Observational data: associations, not effects.
Further findings
| Outcome | Patients with CIED | Controls | Device removal | Retained CIEDs | |
|---|---|---|---|---|---|
| Device removal · within 30 days | 15.8% | Not reported in the abstract | Not reported in the abstract | Not reported in the abstract | controls, device removal, retained CIEDs: not reported in the abstract |
| Cumulative incidence of SAB reinfection and all-cause mortality (landmark analysis) · 180 days | |||||
| Reinfection | Not reported in the abstract | Not reported in the abstract | 2.5% | 5.5% | patients with CIED, controls: not reported in the abstract |
| Mortality | Not reported in the abstract | Not reported in the abstract | 7.8% | 31.2% | patients with CIED, controls: not reported in the abstract |
Cumulative incidence of SAB reinfection and all-cause mortality (landmark analysis) · 180 days
- Significantly lower in patients undergoing device removal compared to those with retained CIEDs
Baseline characteristics by removal status
- Patients who underwent CIED removal were younger and had less comorbidity compared to those with retained CIEDs
Original publication
Device-Removal, Reinfection, and Mortality After Staphylococcus aureus Bacteremia in Patients With Cardiac Implantable Electronic Devices. JACC Adv. Published 20 January 2026. doi:10.
Summarised from the published abstract; every number is checked against it