Coronary disease & ACSCohort study
Diabetes and coronary artery disease as risk factors for dementia
- Cohort study
Authors' conclusion
The combination of diabetes and CAD is associated with an increased rate of dementia, in particular vascular dementia, suggesting that the diabetes-related risk of dementia is partly mediated through concomitant atherosclerotic CVD.
Study context
- Population
- Patients ≥65 years who underwent coronary angiography
- Participants
- 103,859 patients
- Exposure
- Diabetes and/or coronary artery disease (CAD) vs neither
- Neither diabetes nor CADn = 23,189reference
- Diabetesn = 3,876
- CADn = 61,020
- Diabetes and CADn = 15,774
- Outcome
- All-cause dementia, Alzheimer's dementia and vascular dementia
- Follow-up
- Median 6.3 years
Main finding
As reported in the abstract
All-cause dementia
Each group vs neither diabetes nor CADAdjusted hazard ratio (95% CI)
Diabetes and CAD
1.37(1.24–1.51)
Diabetes
1.14(0.97–1.33)
CAD
1.11(1.03–1.20)
- Patients diagnosed with all-cause dementia
- 5592 (5.5%)
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| Alzheimer's dementia | 1.41 (1.23–1.62) | |
| Vascular dementia | 2.03 (1.69–2.45) | |
| 0.512Adjusted hazard ratio (log scale) |
Original publication
Diabetes and coronary artery disease as risk factors for dementia. Eur J Prev Cardiol. Published 29 April 2024. doi:10.1093/eurjpc/zwae153
Summarised from the published abstract; every number is checked against it