Valvular & structural heart disease
Diabetes and elevated plasma glucose in heart valve calcification and disease: the Copenhagen General Population Study
Authors' conclusion
Diabetes and elevated plasma glucose were associated with risk of aortic and mitral valve calcification and aortic valve stenosis. The risk of aortic valve stenosis was partly explained by elevated plasma triglycerides, hypertension, and BMI.
Study context
- Population
- Copenhagen General Population Study; cardiac CT subset for valve calcification12,006 with cardiac CT
- Participants
- 110,291 participants
- Exposure
- Diabetes vs no diabetes; plasma glucose ≥6.6 vs ≤5.1 mmol/L
- Outcome
- Aortic and mitral valve calcification (CT) and aortic valve stenosis (health registers)
Methodological detailsgeneral population, multivariable adjusted
- General population
- Multivariable adjusted
Main finding
As reported in the abstract
Estimate (95% CI)
Diabetesvs No diabetesaortic valve calcification, multivariable adjusted
OR 1.67(1.34–2.08)
Diabetesvs No diabetesmitral valve calcification, multivariable adjusted
OR 1.89(1.48–2.40)
Diabetesvs No diabetesaortic valve stenosis
HR 1.71(1.44–2.03)
Glucose ≥6.6 mmol/Lvs Glucose ≤5.1 mmol/Laortic valve calcification, multivariable adjusted
OR 1.27(1.07–1.52)
Glucose ≥6.6 mmol/Lvs Glucose ≤5.1 mmol/Lmitral valve calcification, multivariable adjusted
OR 1.44(1.18–1.77)
Glucose ≥6.6 mmol/Lvs Glucose ≤5.1 mmol/Laortic valve stenosis
HR 1.33(1.12–1.57)
Observational data: associations, not effects.
Further findings
Valve calcification prevalence (cardiac CT subset)
- Aortic valve calcification
- 3018 (25%)
- Mitral valve calcification
- 1521 (13%)
Proportion of diabetes–aortic valve stenosis association explained (mediation)
- Plasma TG
- 4.8% (95% CI: 0.5-11%)
- Hypertension
- 19% (14-28%)
- Body mass index (BMI)
- 27% (18-43%)
Original publication
Diabetes and elevated plasma glucose in heart valve calcification and disease: the Copenhagen General Population Study. Eur J Prev Cardiol. Published 26 February 2025. doi:10.
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