Diabetic Microvascular Complications Predicts Non-Heart Failure with Reduced Ejection Fraction in Type 2 Diabetes
Authors' conclusion
In patients with T2DM without prior heart failure, non-HFrEF hospitalization was more closely associated with the progression of diabetic microangiopathy than HFrEF.
Study context
- Population
- Patients with T2DM without prior HF
- Participants
- 568 patients70 HF hospitalizations
- Exposure
- Severity of diabetic retinopathy and nephropathy at baseline
- Outcome
- First HF hospitalization classified as HFrEF (LVEF < 40%) or non-HFrEF (LVEF ≥ 40%)
Main finding
As reported in the abstract
Non-HFrEF hospitalization
Adjusted hazard ratio (95% CI)P value
Proliferative retinopathyvs No apparent retinopathy
2.96(1.09–6.83)
P = 0.035Macroalbuminuriavs Normoalbuminuria
4.23(2.24–7.85)
P < 0.001Observational data: associations, not effects.
Further findings
Heart failure with mildly reduced ejection fraction (HFmrEF) (40% ≤ LVEF < 50%) and heart failure with preserved ejection fraction (HFpEF) (50% ≤ LVEF) hospitalization
- HFmrEF and HFpEF hospitalizations also associated with progression of retinopathy and nephropathy
Original publication
Diabetic Microvascular Complications Predicts Non-Heart Failure with Reduced Ejection Fraction in Type 2 Diabetes. ESC Heart Fail. Published 11 January 2023. doi:10.
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