Diagnostic Accuracy of an Integrated Multimodality Imaging Approach in Patients With Cardiac Masses
Authors' conclusion
CMR provides the highest standalone accuracy for malignancy detection. In inconclusive cases, adding 18F-FDG PET further improves diagnostic performance, while CCT combined with 18F-FDG PET represents a reliable alternative.
Study context
- Population
- Patients with suspected cardiac masses; reference standard histology (or radiological resolution after anticoagulation for thrombi)54% malignant
- Participants
- 142 patients
- Comparison
- Echocardiography, cardiac magnetic resonance (CMR), cardiac computed tomography (CCT) and 18F-FDG positron emission tomography (PET), alone and combined, for malignant cardiac masses
- Outcome
- Diagnostic accuracy (AUC) for identifying malignant cardiac masses
Methodological detailsprospective
- Prospective
Performance
As reported in the abstract
Diagnostic accuracy for malignancy
| Test or model | AUC | PPV | NPV |
|---|---|---|---|
| Echocardiography | 0.77 | Not reported in the abstract | Not reported in the abstract |
| CMR | 0.94 | Not reported in the abstract | Not reported in the abstract |
| CCT | 0.85 | Not reported in the abstract | Not reported in the abstract |
| 18F-FDG PET | 0.85 | Not reported in the abstract | Not reported in the abstract |
| CMR + 18F-FDG PET | 0.97 | 95.1% | 100% |
| CCT + 18F-FDG PET | 0.92 | Not reported in the abstract | Not reported in the abstract |
AUC
Echocardiography0.77
CMR0.94
CCT0.85
18F-FDG PET0.85
CMR + 18F-FDG PET0.97
CCT + 18F-FDG PET0.92
PPV
EchocardiographyNot reported in the abstract
CMRNot reported in the abstract
CCTNot reported in the abstract
18F-FDG PETNot reported in the abstract
CMR + 18F-FDG PET95.1%
CCT + 18F-FDG PETNot reported in the abstract
NPV
EchocardiographyNot reported in the abstract
CMRNot reported in the abstract
CCTNot reported in the abstract
18F-FDG PETNot reported in the abstract
CMR + 18F-FDG PET100%
CCT + 18F-FDG PETNot reported in the abstract
Further findings
Incremental value of PET after CMR or CCT (CART analysis)
- Adding PET after CMR or CCT associated with improved diagnostic classification in selected cases
Original publication
Diagnostic Accuracy of an Integrated Multimodality Imaging Approach in Patients With Cardiac Masses. JACC Cardiovasc Imaging. Published 22 May 2026. doi:10.
Summarised from the published abstract; every number is checked against it