Specific locations of myocardial inflammation and fibrosis are associated with higher risk of events in cardiac sarcoidosis
Main finding · EventsResult — go to the resultOdds ratio 5.5 CI 1.1–27.5Authors' conclusion
Involvement of specific myocardial segments, particularly basal to mid-anterior and mid-septal segments, is associated with higher rates of events in patients with suspected cardiac sarcoidosis.
Study context
- Population
- Patients with suspected clinical sarcoidosis undergoing 18F-FDG-PET/magnetic resonance (MR)
- Participants
- 124 patients
- Exposure
- Segmental late gadolinium enhancement (LGE) and 18F-FDG uptake on positron emission tomography (PET)/MR, with vs without events
- With eventsn = 22
- Outcome
- Events: VA (sustained VT, VF, appropriate ICD discharge), HF hospitalization or all-cause death
- Follow-up
- 5.5 years
Main finding
Events · 5.5 years
Odds ratio
5.5
CI 1.1–27.5
P = 0.038
By group
18F-FDG in basal anterior segment
OR 5.5 (CI 1.1–27.5); P = 0.038
As reported in the abstract
- Patients with an event during follow-up
- 22 (17.6%)
Observational data: associations, not effects.
Further findings
- Patients presenting with ventricular arrhythmia (VA)
- 9 (7.2%)
- LGE in basal to mid-anterior, mid-anteroseptal and basal to mid-inferoseptal segments independently predicted VA
- 18F-FDG in basal to mid-anterior, mid-inferoseptal and mid-inferior segments independently predicted VA
Original publication
Specific locations of myocardial inflammation and fibrosis are associated with higher risk of events in cardiac sarcoidosis. Heart Rhythm. Published 10 September 2024. doi:10.
Summarised from the published abstract; every number is checked against it