Heart failure & cardiomyopathies
Diagnostic and prognostic significance of miRNA-15a-5p, 16-5p, and 92a-3p in arrhythmogenic right ventricular cardiomyopathy
Authors' conclusion
This study highlights miRNAs' potential to enhance the diagnosis, disease progression, and clinical outcomes of ARVC, supporting further research to improve patient care.
Study context
- Population
- Arrhythmogenic right ventricular cardiomyopathy (ARVC) patients, stratified by 5-year event-free survival risk, with Brugada syndrome (BrS) patients and healthy controlsARVC patients 102 · Brugada syndrome (BrS) patients 24 · healthy controls 22
- Participants
- 102 / 24 / 22
- Comparison
- Circulating miRNA expression between high- and low-risk ARVC patients, and in ARVC compared with BrS patients and healthy controls
- ARVC patientsn = 102
- Brugada syndrome (BrS) patientsn = 24
- Healthy controlsn = 22
- Outcome
- Differential miRNA expression between high- and low-risk ARVC patients
Main finding
As reported in the abstract
- Six microRNAs (miRNAs) exhibited differential expression between high- and low-risk ARVC patients
- MiR-15a-5p, miR-16-5p, and miR-92a-3p demonstrated the best performance in risk stratification
Further findings
MiR-15a-5p expression in patients with adverse cardiac events
- MiR-15a-5p also displayed higher expression in patients with adverse cardiac events
miRNA expression in ARVC vs BrS patients and healthy controls
- Increased expression of these miRNAs in ARVC
Original publication
Diagnostic and prognostic significance of miRNA-15a-5p, 16-5p, and 92a-3p in arrhythmogenic right ventricular cardiomyopathy. Heart Rhythm. Published 11 April 2025. doi:10.
Summarised from the published abstract; every number is checked against it