Heart failure & cardiomyopathies
Circulating Brain-Derived Neurotrophic Factor Levels and Heart Failure: A Systematic Review and Meta-Analysis
Pooled result · Circulating BDNF levelsResult — go to the resultSMD −2.47 95% CI −4.39 to −0.54Authors' conclusion
BDNF levels are decreased in patients with HF. Most importantly, we observed an association between lower BDNF levels and poor prognosis in patients with HF.
Study context
- Population
- Patients with heart failure (HF) vs non-HF controls; Brain-derived neurotrophic factor (BDNF) as diagnostic and prognostic biomarker11 studies (6 meta-analysed)
- Participants
- 1,420 patients
- Comparison
- Circulating BDNF in HF vs non-HF controls
- HFn = 1,420
- Outcome
- Circulating BDNF levels
Methodological detailsrandom-effects meta-analysis
- Random-effects meta-analysis
Pooled result
As reported in the abstract
SMD
−2.47
95% CI −4.39 to −0.54
P = 0.01
HF vs Healthy controls
SMD −2.47 (95% CI −4.39 to −0.54); P = 0.01
Further pooled results
BDNF by NYHA class
- Higher NYHA class associated with lower BDNF levels
All-cause mortality and HF rehospitalization
- Associated with lower BDNF levels in individual studies
Original publication
Circulating Brain-Derived Neurotrophic Factor Levels and Heart Failure: A Systematic Review and Meta-Analysis. ESC Heart Fail. Published 24 June 2024. doi:10.
Summarised from the published abstract; every number is checked against it