Diagnostic Performance of Angiography-Derived Quantitative Flow Ratio in Complex Coronary Lesions
Authors' conclusion
Angiography-derived quantitative flow ratio (CT-QFR and μQFR) demonstrated remarkable diagnostic performance in complex coronary lesions
Study context
- Population
- Patients with 30% to 90% coronary diameter stenosis who underwent both coronary CT angiography and invasive coronary angiography with FFR within 60 days, September 2014–September 2021
- Participants
- 240 patients
- Comparison
- CT-QFR and μQFR vs invasive FFR
- Outcome
- Diagnostic performance in detecting functional ischemia, using FFR as reference standard
Methodological detailsretrospective
- Retrospective
Performance
As reported in the abstract
Diagnostic performance, all lesions, per-vessel level
| Test or model | Sensitivity | Specificity | PPV | NPV | Accuracy |
|---|---|---|---|---|---|
| CT-QFR | 91% (95% CI, 84%-96%)Sensitivity on a scale from 0 to 100 percent | 92% (95% CI, 88%-95%)Specificity on a scale from 0 to 100 percent | 83% (95% CI, 75%-90%) | 96% (95% CI, 93%-98%) | 92% (95% CI, 88%-95%) |
| μQFR | 90% (95% CI, 81%-95%)Sensitivity on a scale from 0 to 100 percent | 97% (95% CI, 93%-99%)Specificity on a scale from 0 to 100 percent | 92% (95% CI, 84%-97%) | 96% (95% CI, 92%-98%) | 94% (95% CI, 91%-97%) |
Sensitivity
CT-QFR91% (95% CI, 84%-96%)
μQFR90% (95% CI, 81%-95%)
Sensitivity on a scale from 0 to 100 percentSpecificity
CT-QFR92% (95% CI, 88%-95%)
μQFR97% (95% CI, 93%-99%)
Specificity on a scale from 0 to 100 percentPPV
CT-QFR83% (95% CI, 75%-90%)
μQFR92% (95% CI, 84%-97%)
NPV
CT-QFR96% (95% CI, 93%-98%)
μQFR96% (95% CI, 92%-98%)
Accuracy
CT-QFR92% (95% CI, 88%-95%)
μQFR94% (95% CI, 91%-97%)
Further findings
Accuracy in the gray zone
Complex lesions (bifurcation, tandem, moderate-to-severe calcified), vessel level
- CT-QFR and μQFR showed great correlation and agreement with invasive FFR; AUC exceeding 0.9 for each complex lesion
- >0.9
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Diagnostic Performance of Angiography-Derived Quantitative Flow Ratio in Complex Coronary Lesions. Circ Cardiovasc Imaging. Published 19 March 2024. doi:10.
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