Dietary Acculturation Is Associated With Altered Gut Microbiome, Circulating Metabolites, and Cardiovascular Disease Risk in US Hispanics and Latinos: Results From HCHS/SOL
Main finding · Incident CVD per SD of dietary acculturation scoreResult — go to the resultHazard ratio 1.33 95% CI 1.13–1.57Authors' conclusion
Among US Hispanic and Latino adults, greater dietary acculturation was associated with elevated CVD risk, possibly through alterations in gut microbiota and related metabolites.
Study context
- Population
- US Hispanic and Latino adults (HCHS/SOL)211 cardiovascular disease (CVD) cases
- Participants
- 14,172 participants
- Exposure
- Higher vs lower dietary acculturation score
- Outcome
- Incident CVD
- Follow-up
- ≈7 years
Main finding
As reported in the abstract
Incident CVD per SD of dietary acculturation score
Hazard ratio
1.33
95% CI 1.13–1.57
Dietary acculturation score (per SD)
HR 1.33 (95% CI 1.13–1.57)
Per SD, as printed
Observational data: associations, not effects.
Further findings
Gut microbial species associated with dietary acculturation · visit 2, 2014 to 2017
- Microbial species associated
- 69
- Enriched species
- 17
- Depleted species, mainly fiber-utilizing Clostridia and Prevotella
- 52
- n=2349
Metabolites associated with both diet acculturation-related gut microbiota and incident CVD
- Metabolites, mainly fatty acid and glycerophospholipid metabolism
- 25
Proxy association of diet acculturation-related microbiome with CVD risk
- Positive relationship (r)
- 0.70, P<0.001
Original publication
Dietary Acculturation Is Associated With Altered Gut Microbiome, Circulating Metabolites, and Cardiovascular Disease Risk in US Hispanics and Latinos: Results From HCHS/SOL. Circulation. Published 19 June 2024. doi:10.
Summarised from the published abstract; every number is checked against it