Differences in HDL-related mortality risk between individuals with and without hypertension: a prospective cohort study in UK Biobank
Authors' conclusion
The increased risk of mortality associated with very high HDL-C existed only in individuals with hypertension, but not in those without hypertension. Moreover, the increased risk at high HDL-C levels in hypertension was likely driven by larger HDL-P.
Study context
- Population
- UK Biobank participants with and without hypertension244,866 with hypertension
- Participants
- 429,792 participants
- Exposure
- Very high vs normal high-density lipoprotein cholesterol (HDL-C), stratified by hypertension
- Outcome
- All-cause mortality
- Follow-up
- Median 12.7 years
Main finding
As reported in the abstract
All-cause mortality, by hypertension (subgroup analysis)
Very high HDL-C vs Normal HDL-CHazard ratio (95% CI)
With hypertension
1.47(1.35–1.61)
Without hypertension
1.05(0.91–1.22)
Observational data: associations, not effects.
Further findings
Deaths, by hypertension · median follow-up 12.7 years
HDL particle size and all-cause mortality (hypertension)
- Larger HDL particle (HDL-P) positively, smaller HDL-P negatively associated with all-cause mortality
- After adjustment for larger HDL-P, U-shaped HDL-C association became L-shaped
Original publication
Differences in HDL-related mortality risk between individuals with and without hypertension: a prospective cohort study in UK Biobank. Eur J Prev Cardiol. Published 21 February 2023. doi:10.
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