Long-term cardiometabolic health in people born after assisted reproductive technology: a multi-cohort analysis
Authors' conclusion
These findings of small and statistically non-significant differences in offspring cardiometabolic outcomes should reassure people receiving ART.
Study context
- Population
- Offspring in population-based birth cohorts; mean age 13 months to 27.4 years (<10 years in 11/14 cohorts)
- Participants
- 35,938 offspring14 cohorts
- Comparison
- ART conception vs natural conception
- ARTn = 654
- Outcome
- Differences in SBP, DBP, HR, lipids and hyperglycaemic/insulin resistance markers
Methodological details14 population-based birth cohorts, Europe, Australia and Singapore, trajectory modelling of 4 cohorts with repeated measures
- 14 population-based birth cohorts
- Europe, Australia and Singapore
- Trajectory modelling of 4 cohorts with repeated measures
Pooled result
As reported in the abstract
Cardiometabolic outcomes (ART minus NC)
ART vs NCDifference, mmHg (95% CI)
SBP
−0.53(−1.59 to 0.53)
DBP
−0.24(−0.83 to 0.35)
ART vs NCDifference, beat/min (95% CI)
HR
0.02(−0.91 to 0.94)
ART vs NCDifference, % (95% CI)
Total cholesterol
2.59(0.10–5.07)
HDL cholesterol
4.16(2.52–5.81)
LDL cholesterol
4.95(0.47–9.43)
Further pooled results
Trajectories of cardiometabolic outcomes from 2 to 26 years (4 cohorts)
- ART associated with lower predicted SBP/diastolic blood pressure (DBP) in childhood (statistically significant)
- Subtle trajectories to higher SBP and triglycerides (TG) in young adulthood
- Most differences not statistically significant
- 17 244 (244 ART) births
Original publication
Long-term cardiometabolic health in people born after assisted reproductive technology: a multi-cohort analysis. Eur Heart J. Published 6 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →