Valvular & structural heart disease
Differences in Myocardial Remodeling and Tissue Characteristics in Chronic Isolated Aortic and Mitral Regurgitation
Authors' conclusion
Cardiac magnetic resonance identified significant heterogeneity in remodeling patterns and tissue characteristics at matched degrees of AR and MR.
Study context
- Population
- Patients with chronic isolated aortic regurgitation (AR) or primary mitral regurgitation (MR) assessed by cardiac magnetic resonance
- Participants
- 664 patients
- Exposure
- Isolated AR vs isolated primary MR
- ARn = 240
- MRn = 424reference
- Outcome
- LV remodeling patterns
Main finding
As reported in the abstract
Eccentric hypertrophy (≥moderate regurgitation)
P < 0.001
| Outcome | AR | MR |
|---|---|---|
| Normal geometry (≥moderate regurgitation) | — not stated in the abstract | 56.7% |
| Myocardial thinning with low mass/volume ratio (≥moderate regurgitation) | — not stated in the abstract | 18.4% |
— not stated in the abstract
- AR led to more pronounced increases in ventricular volume and mass vs MR across the spectrum of regurgitant volume
- P < 0.001
Observational data: associations, not effects.
Further findings
Symptom status by remodeling pattern
- Eccentric hypertrophy and myocardial thinning more common in symptomatic AR and MR patients
- P < 0.001
CMR-based systemic cardiac index
- Unchanged across the spectrum of AR; progressively declined with increasing MR volume
Myocardial scarring (LGE) and extracellular volume
- MR: higher prevalence of scarring and higher ECV with increasing regurgitant volume
- P for trend < 0.001
- AR: unchanged across the spectrum (scarring; ECV)
- P = 0.24 and 0.42
Original publication
Differences in Myocardial Remodeling and Tissue Characteristics in Chronic Isolated Aortic and Mitral Regurgitation. Circ Cardiovasc Imaging. Published 7 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →