Heart failure & cardiomyopathies
Different Phases of Disease in Lymphocytic Myocarditis: Clinical and Electrophysiological Characteristics
Authors' conclusion
LM is a highly heterogeneous disease, and its different phases are characterized by diverse clinical, morphological, and electrophysiological features.
Study context
- Population
- Patients with biopsy-proven lymphocytic myocarditis at 3 Italian referral centres
- Participants
- 122 patients
- Exposure
- Acute myocarditis (AM) vs chronic active myocarditis (CAM) vs healed myocarditis (HM)
- AMn = 44
- CAMn = 42
- HMn = 36
- Outcome
- Clinical, CMR and electrophysiological features by LM phase
Methodological detailsmulticentre, 3 Italian referral centres
- Multicentre
- 3 Italian referral centres
Main finding
As reported in the abstract
LGE on CMR
Edema on CMR
- Complex ventricular arrhythmias overall
- n = 109, 89%
- VF slightly more prevalent in AM
- P = 0.028
- LGE difference across phases
- P < 0.001
- Edema difference across phases
- P < 0.001
- Segmental edema vs normal voltage at that site, OR 0.24 (95% CI 0.10-0.54)
- P < 0.01
- LGE vs low-voltage areas, OR 2.86 (95% CI 1.19-6.97)
- P = 0.019
Observational data: associations, not effects.
Original publication
Different Phases of Disease in Lymphocytic Myocarditis: Clinical and Electrophysiological Characteristics. JACC Clin Electrophysiol. Published 30 November 2022. doi:10.
Summarised from the published abstract; every number is checked against it