Heart failure & cardiomyopathies
Differential Associations of Cardiac, Pulmonary, Arterial, and Muscle Physiological Parameters and Biomarkers With the Incidence of Heart Failure with Preserved Ejection Fraction (HFpEF) and Heart Failure with Reduced Ejection Fraction (HFrEF)
Authors' conclusion
Among older adults, subclinical LV systolic dysfunction and remodeling differentially predicted the risk of incident HFrEF, whereas diastolic and most noncardiac dysfunctions were associated similarly with both incident HFpEF and HFrEF.
Study context
- Population
- Older adults in the ARIC study attending visit 5 (2011–2013)ARIC visit 5
- Participants
- 5,484 adults
- Exposure
- HFpEF vs HFrEF
- Outcome
- Incident adjudicated HFpEF and HFrEF
- Follow-up
- Median 7 years (range: 6-8 years)
Methodological detailscommunity-based cohort (ARIC)
- Community-based cohort (ARIC)
Main finding
As reported in the abstract
Incident HF · median 7 years
HFpEF
220
events
HFrEF
187
events
Observational data: associations, not effects.
Further findings
Events
| Outcome | HFpEF | HFrEF |
|---|---|---|
| Prevalent HF | 246 | 81 |
Prevalent HF
- Worse left ventricular (LV) and RV systolic function and larger LV size more strongly associated with prevalent HFrEF
- Higher body mass index (BMI) more strongly associated with prevalent HFpEF
Original publication
Differential Associations of Cardiac, Pulmonary, Arterial, and Muscle Physiological Parameters and Biomarkers With the Incidence of HFpEF and HFrEF. JACC Heart Fail. Published 13 June 2025. doi:10.
Summarised from the published abstract; every number is checked against it