Heart failure & cardiomyopathies

Digital Implementation Strategy to Increase SGLT2 Inhibitor Uptake in Heart Failure: Study Design of EMAIL-HF

ESC Heart FailPublished Randomised controlled trial

Authors' conclusion

EMAIL-HF will determine whether a population-wide digital strategy can increase and accelerate guideline-based initiation of SGLT2 inhibitors in patients with chronic HF.

Study context

Population
Patients with heart failure (HF) diagnosed within the last 10 years, not treated with SGLT2 inhibitors, Capital Region of Denmark and Roskildedesign paper
Participants
5,996 patients
Comparison
Digital letter on SGLT2 inhibitors with invitation for evaluation vs usual care
  • Interventionn = 2,979
  • Controln = 3,017reference
Primary endpoint
Proportion of patients initiating SGLT2 inhibitor therapy
Follow-up
Within 6 months after randomization
Methodological detailspragmatic, registry-based
  • Pragmatic
  • Registry-based

Primary result

As reported in the abstract

  • Outcomes will be reported after completion of event accrual

Original publication

Digital Implementation Strategy to Increase SGLT2 Inhibitor Uptake in Heart Failure: Study Design of EMAIL-HF. ESC Heart Fail. Published 25 August 2025. doi:10.1002/ehf2.15398

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