Arrhythmias & electrophysiology

Direct Oral Anticoagulants in Primary and Secondary Prevention of Thrombotic Events: 2026 ACC Scientific Statement: A Report of the American College of Cardiology

J Am Coll CardiolPublished Scientific statement

Scope

As issued by the authors

Established and emerging indications for DOAC therapy in primary and secondary prevention of thrombotic events: AF, acute and extended VTE treatment, special populations (CKD, liver dysfunction, cancer, obesity, frailty, prior bleeding, valvular heart disease), periprocedural anticoagulation, antithrombotic strategies after stroke, left atrial appendage closure and catheter ablation; drug selection, dosing, duration, bleeding risk and management, drug-drug interactions, adherence, cost barriers

Original publication

Direct Oral Anticoagulants in Primary and Secondary Prevention of Thrombotic Events: 2026 ACC Scientific Statement: A Report of the American College of Cardiology. J Am Coll Cardiol. Published 30 June 2026. doi:10.1016/j.jacc.2026.05.033

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