Heart failure & cardiomyopathiesCohort study
Disparities Among Immigrants and Native Patients in Denmark With New-Onset Heart Failure With Reduced Ejection Fraction
- Registry-based cohort study
- nationwide registry
Authors' conclusion
Patients in Denmark with HFrEF originating from non-Western parts of the world were younger and had more ischemic heart disease and diabetes and less atrial fibrillation compared with native Danish patients. The likelihood of GDMT uptitration at 12 months was similar to that of native Danish patients, whereas their risk of HF hospitalization or all-cause death was lower, although the difference between the 2 groups diminished in age- and sex-matched analyses.
Study context
- Population
- Patients in Denmark with new-onset Heart Failure with Reduced Ejection Fraction (HFrEF), Danish Heart Failure Registry
- Participants
- 55,918 patients
- Exposure
- Immigrants by region of origin vs native Danish patients
- Outcome
- Co-primary: uptitration of GDMT; composite of HF hospitalization and all-cause death
Main finding
As reported in the abstract
| Group | Value | Share of cohort |
|---|---|---|
| Native Danish | 94.8% | 94.8% |
| Europe/Central Asia | 3.0% | 3.0% |
| Middle East/North Africa | 1.1% | 1.1% |
| South Asia | 0.6% | 0.6% |
| Other regions | 0.5% | 0.5% |
Observational data: associations, not effects.
Further findings
Baseline characteristics: non-Western immigrants vs Danish patients
- Median age, non-Western vs Danish (years)
- 62 vs 72
- Diabetes
- 38%-50% vs 20%
- Ischemic heart disease
- 67%-74% vs 48%
- AF
- 9%-15% vs 32%
- all P < 0.001
Original publication
Disparities Among Immigrants and Native Patients in Denmark With New-Onset Heart Failure With Reduced Ejection Fraction. JACC Heart Fail. Published 5 February 2025. doi:10.1016/j.jchf.2024.11.008
Summarised from the published abstract; every number is checked against it