Heart failure & cardiomyopathies

Long-term cardiovascular outcomes among immigrants and non-immigrants in cardiac resynchronization therapy: a nationwide study

EuropacePublished Nationwide registry-based cohort study

Authors' conclusion

No overall differences in efficacy of CRT in improving outcomes between immigrants and non-immigrants were identified.

Study context

Population
Patients with heart failure (HF) undergoing first-time cardiac resynchronization therapy (CRT) implantation in Denmark, 2000–2017
Participants
369 vs 7,855
Exposure
Immigrants vs non-immigrants after CRT
  • Immigrantsn = 369
  • Non-immigrantsn = 7,855reference
Outcome
HF-related hospitalizations and all-cause mortality
Follow-up
Up to 5 years
Methodological detailsnationwide registries, Follow-up up to 5 years; Cox regression analyses
  • Nationwide registries
  • Follow-up up to 5 years; Cox regression analyses

Main finding

5-year all-cause mortality

Hazard ratio

1.2

95% CI 0.8–1.7

P = 0.50

By group

Immigrantsvs Non-immigrants
HR 1.2 (95% CI 0.8–1.7); P = 0.50

As reported in the abstract

Observational data: associations, not effects.

Further findings

HF-related hospitalizations, year before vs year after CRT

Year before CRT

Year after CRT

CV causes of death (share of deaths)

OutcomeHR (95% CI)
Mortality, immigrants of Middle Eastern origin (subgroup)Middle Eastern immigrantsvs Non-immigrants2.2 (1.2–4.1)

HF-related hospitalizations, year before vs year after CRT

Consistent reduction in HF-related hospitalizations in both groups

HF guideline-directed pharmacotherapy before and after CRT

Similar high uptake in both groups

Original publication

Long-term cardiovascular outcomes among immigrants and non-immigrants in cardiac resynchronization therapy: a nationwide study. Europace. Published 19 June 2023. doi:10.1093/europace/euad148

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