Heart failure & cardiomyopathies
Disparities in prescriptions among Danish heart failure patients: a national longitudinal cohort study
Authors' conclusion
Substantial disparity was found in prescriptions for the potentially life-saving medications, with lack of prescriptions being associated with lower education, lower income and several demographic characteristics.
Study context
- Population
- Danish HF patients diagnosed on or after the updated ESC guidelines, universal healthcare system
- Participants
- 43,625 vs 2,819
- Exposure
- Demographic, geographic and socioeconomic factors and prescription of angiotensin receptor-neprilysin inhibitors (ARNi) and SGLT2i
- ARNin = 43,625
- SGLT2in = 2,819
- Outcome
- Redemption of a prescription for ARNi or SGLT2i
Methodological detailsnational registers, longitudinal, Follow-up until prescription redemption, emigration, death or censoring on 30 June 2022; Aalen-Johansen estimator and Cox models
- National registers
- Longitudinal
- Follow-up until prescription redemption, emigration, death or censoring on 30 June 2022; Aalen-Johansen estimator and Cox models
Main finding
As reported in the abstract
Factors associated with lack of prescriptions (women, older age, living alone, non-native Danish or descendant)
Hazard ratio (95% CI)
ARNilowest HR of the range
0.31(0.28–0.36)
ARNihighest HR of the range
0.86(0.80–0.93)
SGLT2ilowest HR of the range
0.49(0.41–0.58)
SGLT2ihighest HR of the range
0.93(0.72–1.20)
Observational data: associations, not effects.
Further findings
Social gradient in prescriptions
- Social gradient for both ARNi and SGLT2i; statistically significant for ARNi
Original publication
Disparities in prescriptions among Danish heart failure patients: a national longitudinal cohort study. Heart. Published 10 May 2025. doi:10.
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