Distinct child-to-adult body mass index trajectories are associated with different levels of adult cardiometabolic risk
Authors' conclusion
The long-term BMI trajectories that reach or persist at high levels associate with CVD risk factors in adulthood.
Study context
- Population
- Cardiovascular Risk in Young Finns Study participants followed from childhood to adulthood (6–49 years)
- Participants
- 2,631 participants
- Exposure
- Child-to-adult body mass index (BMI) trajectories vs stable normal BMI
- Outcome
- Adult CVD risk factors: T2DM, high-risk lipid levels, hypertension, high cIMT
- Follow-up
- Adulthood (34-49 years)
Methodological detailslongitudinal, latent class growth mixture modelling
- Longitudinal
- Latent class growth mixture modelling
Main finding
As reported in the abstract
Adult CVD risk factors (T2DM, high-risk lipids, hypertension, high cIMT) by BMI trajectory · adulthood (24-49 years)
Relative risk
2.6
95% CI 0.14–8.23
Resolvingvs Stable normal
RR 2.6 (95% CI 0.14–8.23)
- Worsening or persisting obesity trajectories vs stable normal: increased risk of adult cardiovascular disease (CVD) outcomes
- all risk ratios (RRs) >15, P < 0.05
- Resolving vs never obese or overweight: similar risk of dyslipidaemia and hypertension
- all RRs close to 1
- Resolving (elevated child BMI resolved) vs stable normal: significantly higher risk of increased carotid intima-media thickness (cIMT)
- RR = 3.37, 95% CI = 1.80-6.39
Observational data: associations, not effects.
Original publication
Distinct child-to-adult body mass index trajectories are associated with different levels of adult cardiometabolic risk. Eur Heart J. Published 4 April 2018. doi:10.
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