Heart failure & cardiomyopathies
Distinctive left ventricular–arterial and right ventricular–pulmonary arterial coupling observed in patients with heart failure and a higher left ventricular ejection fraction range
An erratum to this article was published (Eur Heart J Cardiovasc Imaging, 31 May 2024 ↗)
Authors' conclusion
HFpEF patients with higher LVEF have unfavourable prognosis and distinctive LV-A coupling: Ees/Ea is elevated up to 2.0 or more. Impaired RV-PA coupling also worsens prognosis in such patients.
Study context
- Population
- Patients hospitalized for acute decompensated heart failure (HF) with LVEF > 40%
- Participants
- 255 patients
- Exposure
- HFpEF with LVEF ≥ 60% vs HFpEF with 50% ≤ LVEF < 60% vs HF with mildly reduced EF (HFmrEF)
- Outcome
- Ees/elastance (Ea) (left ventricular (LV)-arterial coupling)
Main finding
As reported in the abstract
HFpEF LVEF ≥ 60%
2.12
± 0.57
HFpEF 50% ≤ LVEF < 60%
1.20
± 0.14
HFmrEF
0.82
± 0.09
P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| TAPSE/PASP (RV-PA coupling)Did not differ among groups (n = 168) | P = 0.17 |
All-cause death and HF readmission-free survival
- Worse in the group with a higher LVEF range
TAPSE/PASP (RV-PA coupling)
- PASP increased in groups with higher LVEF
Predictors of event-free survival (multivariate Cox)
- TAPSE/PASP but not PASP significantly related to event-free survival independent of LVEF
Original publication
Distinctive left ventricular–arterial and right ventricular–pulmonary arterial coupling observed in patients with heart failure and a higher left ventricular ejection fraction range. Eur Heart J Cardiovasc Imaging. Published 29 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →