Heart failure & cardiomyopathies
Conduction System Stimulation to Avoid Left Ventricle Dysfunction
Primary result · LVEFResult — go to the resultMean difference −5.8 % 95% CI −9.6% to −2%Authors' conclusion
Conduction system stimulation prevents LVEF deterioration and heart failure-related admissions in patients with normal or mildly deteriorated LVEF requiring a high burden of ventricular pacing.
Study context
- Population
- Consecutive patients with high-degree atrioventricular block and left ventricular ejection fraction (LVEF) >40% requiring a high burden of ventricular pacing70 in ITT analyses
- Participants
- 75 patients
- Comparison
- Conduction system pacing (CSP) vs conventional right ventricular apical pacing (RVAP)
- Primary endpoint
- Change in LVEF
- Follow-up
- 6 months
Methodological detailsprospective, parallel
- Prospective
- Parallel
Primary result
LVEF
Mean difference
−5.8 %
95% CI −9.6% to −2%
P < 0.01
RVAPvs CSP
mean difference −5.8 % (95% CI −9.6% to −2%); P < 0.01
As reported in the abstract
Further findings
Stimulated QRS duration
P < 0.01
| Outcome | Mean difference (mm) (95% CI) | P value | |
|---|---|---|---|
| LV end-diastolic diameterIncrease with RVAP | 3.2 (0.1–6.2) | P = 0.04 | |
| −50510Difference, mm (linear scale) |
Safety
HF-related admissions
P = 0.03
Original publication
Conduction System Stimulation to Avoid Left Ventricle Dysfunction. Circ Arrhythm Electrophysiol. Published 29 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →