Heart failure & cardiomyopathies
Diuresis Efficacy in Ambulatory Congested Heart Failure Patients: Intrapatient Comparison of 3 Diuretic Regimens (DEA-HF)
Authors' conclusion
In ambulatory CHF patients, furosemide plus metolazone resulted in a significantly higher natriuresis compared with IV furosemide alone or furosemide plus acetazolamide.
Study context
- Population
- Ambulatory NYHA class II–intravenous (IV) chronic HF patients treated in a day-care unitcrossover
- Participants
- 42 patients
- Comparison
- IV furosemide alone vs furosemide plus metolazone vs furosemide plus acetazolamide
- Primary endpoint
- Total sodium excretion
- Follow-up
- 6 hours post-treatment initiation
Methodological detailsprospective, open-label, 6 randomised sequences
- Prospective
- Open-label
- 6 randomised sequences
Primary result
As reported in the abstract
Sodium excreted · 6 hours
Furosemide plus metolazone vs Furosemide: P = 0.015 · Furosemide plus metolazone vs Furosemide plus acetazolamide: P = 0.001
Further findings
Total urinary volume · 6 hours
P = 0.039
Safety
Worsening renal function
- Worsening renal function: P < 0.001
Original publication
Diuresis Efficacy in Ambulatory Congested Heart Failure Patients: Intrapatient Comparison of 3 Diuretic Regimens (DEA-HF). JACC Heart Fail. Published 11 May 2024. doi:10.
Summarised from the published abstract; every number is checked against it