Heart failure & cardiomyopathies
Diuretic Dose is a Strong Prognostic Factor in Ambulatory Patients Awaiting Heart Transplantation
Main finding · Waitlist death/urgent HTResult — go to the resultAdjusted hazard ratio 2.23 CI 1.33–3.73Authors' conclusion
A 'high dose' of loop diuretics is strongly associated with residual congestion and is a predictor of outcome in patients awaiting HT despite adjustment for classical cardiorenal risk factors.
Study context
- Population
- Ambulatory patients on the French national heart transplantation waiting list, 2013–2019median age 55 years, 70% men
- Participants
- 700 patients
- Exposure
- High or intermediate vs low dose loop diuretics
- Outcome
- Waitlist death or urgent heart transplantation
- Follow-up
- 12 months
Methodological detailsFrench national heart transplantation (HT) waiting list
- French national HT waiting list
Main finding
Waitlist death/urgent HT
Adjusted hazard ratio
2.23
CI 1.33–3.73
P = 0.002
By group
High dosevs Low dose
adjusted HR 2.23 (CI 1.33–3.73); P = 0.002
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted HR (CI) | P value | |
|---|---|---|---|
| Waitlist deathHigh dosevs Low dose | 6.18 (2.16–17.72) | P < 0.001 | |
| 0.050.21520Adjusted hazard ratio (log scale) |
| Outcome | P value |
|---|---|
| Waitlist deathIntermediate dose vs Low dose · not significant in adjusted models | P > 0.05 |
NT-proBNP, creatinine, PCWP, pulmonary pressures
- Gradually increased with higher diuretic dose
Original publication
Diuretic Dose is a Strong Prognostic Factor in Ambulatory Patients Awaiting Heart Transplantation. ESC Heart Fail. Published 5 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →