Heart failure & cardiomyopathies
Diuretic Efficiency of a Single Dose of Subcutaneous Versus Oral Furosemide After Heart Failure Hospitalization Across Diuretic Resistance Strata: A Pilot Randomized Controlled Trial
Authors' conclusion
Single-dose sc furosemide was associated with greater diuretic efficiency and peak urine sodium than oral furosemide in participants with DR discharged following recent HF hospitalization.
Study context
- Population
- Patients within 14 days after heart failure (HF) hospitalization, stratified by diuretic resistance (admission BAN-ADHF score ≥12)46 with diuretic resistance (DR)
- Participants
- 70 patients
- Comparison
- Single-dose SC furosemide vs home oral furosemide
- Primary endpoint
- Diuretic efficiency (total urine output per mg of diuretic) and peak urine sodium
- Follow-up
- Within 8 h of dose administration
Methodological detailsopen-label, pilot, stratified by diuretic resistance (2:1 DR vs no DR)
- Open-label
- Pilot
- Stratified by diuretic resistance (2:1 DR vs no DR)
Primary result
As reported in the abstract
Diuretic efficiency and peak urine sodium, by DR stratum · within 8 h
| Group | Diuretic efficiency, DR | Peak urine sodium, DR | Diuretic efficiency, no DR | Peak urine sodium, no DR |
|---|---|---|---|---|
| SC furosemide | 34.0 ml/mg | 100 mmol/L | 29.8 ml/mg | 96 mmol/L |
| Oral furosemide | 22.6 ml/mg | 83 mmol/L | 30.1 ml/mg | 95 mmol/L |
Diuretic efficiency, DR
SC furosemide34.0 ml/mg
Oral furosemide22.6 ml/mg
Peak urine sodium, DR
SC furosemide100 mmol/L
Oral furosemide83 mmol/L
Diuretic efficiency, no DR
SC furosemide29.8 ml/mg
Oral furosemide30.1 ml/mg
Peak urine sodium, no DR
SC furosemide96 mmol/L
Oral furosemide95 mmol/L
- SC furosemide vs Oral furosemide: P = 0.002 — diuretic efficiency, DR
- SC furosemide vs Oral furosemide: P = 0.029 — peak urine sodium, DR
- SC furosemide vs Oral furosemide: P = 0.94 — diuretic efficiency, no DR
- SC furosemide vs Oral furosemide: P = 0.93 — peak urine sodium, no DR
Original publication
Diuretic Efficiency of a Single Dose of Subcutaneous Versus Oral Furosemide After Heart Failure Hospitalization Across Diuretic Resistance Strata: A Pilot Randomized Controlled Trial. Eur J Heart Fail. Published 2 December 2024. doi:10.
Summarised from the published abstract; every number is checked against it