Heart failure & cardiomyopathies
Optimal Initial Intravenous Loop Diuretic Dosing in Acute Decompensated Heart Failure
Authors' conclusion
Among patients with ADHF, higher home loop diuretic dose was strongly associated with a substantially lower likelihood of optimal initial IV diuretic dosing.
Study context
- Population
- Adults admitted to a large US hospital for ADHF on home oral loop diuretics, 2014–2021
- Participants
- 3,269 adults
- Exposure
- High and medium vs low home oral loop diuretic dose
- Outcome
- Optimal initial IV loop diuretic dosing (≥2 times home oral dose)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Optimal initial IV dosing
Each group vs lowAdjusted prevalence ratio (95% CI)
High
0.05(0.03–0.07)
Medium
0.66(0.62–0.70)
- Optimal initial intravenous (IV) dosing, overall
- 2,218 (67.9%)
Observational data: associations, not effects.
Further findings
Length of stay and 30-day readmission, optimal vs suboptimal initial IV dosing
- No difference in length of stay or 30-day readmission
Original publication
Optimal Initial Intravenous Loop Diuretic Dosing in Acute Decompensated Heart Failure. JACC Adv. Published 7 September 2024. doi:10.
Summarised from the published abstract; every number is checked against it