Heart failure & cardiomyopathies
Diverging Role of Epicardial Adipose Tissue Across the Entire Heart Failure Spectrum
Authors' conclusion
Although less EAT is present in HFrEF than in HFpEF, only in HFrEF EAT is associated with vascular dysfunction.
Study context
- Population
- Patients with heart failure (HF) across the entire EF spectrum
- Participants
- 258 patients
- Exposure
- Epicardial adipose tissue (EAT) thickness and vascular function across HF with reduced ejection fraction (HFrEF), HF with mildly reduced ejection fraction (HFmrEF) and HF with preserved ejection fraction (HFpEF)
- HFrEFn = 168
- HFpEFn = 50reference
- HFmrEFn = 32
- Outcome
- Association between EAT thickness (transthoracic echocardiography) and endothelial function (FIDart%, FMD%)
Main finding
As reported in the abstract
EAT thickness
P < 0.001
- HFrEF: EAT vs FIDart% correlation r
- −0.213, P = 0.012
- HFrEF: EAT vs FMD% correlation r
- −0.186, P = 0.022
- HFrEF: EAT vs FIDart% adjusted standardized regression coefficient (SRC) (age, BMI, hypertension, DM)
- −0.184, P = 0.049
- HFrEF: EAT vs FMD% adjusted SRC (age, BMI, hypertension, DM)
- −0.178, P = 0.043
Observational data: associations, not effects.
Original publication
Diverging Role of Epicardial Adipose Tissue Across the Entire Heart Failure Spectrum. ESC Heart Fail. Published 11 September 2023. doi:10.
Summarised from the published abstract; every number is checked against it