Heart failure & cardiomyopathies
Epicardial Adipose Tissue, Functional Status, and Invasive Hemodynamics in Heart Failure With Preserved Ejection Fraction
Authors' conclusion
EAT thickness was associated with impaired quality of life, lower 6-MWD, and higher left-sided filling pressures at peak exercise.
Study context
- Population
- Patients with HFpEF undergoing echocardiography and invasive hemodynamic assessment at rest and during ergometry
- Participants
- 566 patients
- Exposure
- Epicardial adipose tissue (EAT) thickness tertiles
- Outcome
- 6-MWD across EAT thickness tertiles
Main finding
As reported in the abstract
P = 0.001
Observational data: associations, not effects.
Further findings
| Outcome | Values | P value |
|---|---|---|
| KCCQ overall summary score across EAT tertilesHighest EAT tertile vs Lowest EAT tertile · significantly lower with increasing EAT tertiles | Lowest EAT tertile 51 (spread 32–67) · Middle EAT tertile 45 (spread 32–63) · Highest EAT tertile 41 (spread 26–56) | P = 0.003 |
| PCWP at peak exerciseHighest EAT tertile vs Lowest and middle EAT tertiles | Highest EAT tertile 36 (SD 8) mm Hg · Lowest and middle EAT tertiles 34 (SD 8) mm Hg | P = 0.009 |
| PCWP to right atrial pressure gradient at peak exerciseHighest EAT tertile vs Lowest and middle EAT tertiles | Highest EAT tertile 18 (SD 7) mm Hg · Lowest and middle EAT tertiles 16 (SD 7) mm Hg | P = 0.002 |
- KCCQ overall summary score across EAT tertiles — Independent of BMI
- P = 0.004
Invasive hemodynamics at rest
- Not different across EAT tertiles
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Epicardial Adipose Tissue, Functional Status, and Invasive Hemodynamics in Heart Failure With Preserved Ejection Fraction. JACC Adv. Published 27 August 2025. doi:10.
Summarised from the published abstract; every number is checked against it