Intravascular Ultrasound (IVUS) or Angiography Guidance for Percutaneous Coronary Intervention in Complex Coronary Bifurcation Lesions: The DKCRUSH VIII Randomized Clinical Trial
Primary resultResult — go to the resultHazard ratio 0.40 95% CI 0.23–0.71Authors' conclusion
In the present randomized trial comparing IVUS-guided vs angiography-guided PCI for complex coronary bifurcation lesions treated with the 2-stent DK crush technique, the benefits of IVUS-guided PCI at 1 year was achieved largely through achievement of IVUS-defined optimization targets rather than IVUS use alone.
Study context
- Population
- Patients with clinical indications for percutaneous coronary intervention (PCI) and a complex bifurcation lesion by DEFINITION criteria (particularly side branch lesion length ≥10 mm)
- Participants
- 555 patients
- Comparison
- IVUS-guided PCI vs angiography-guided PCI
- IVUS-guided PCIn = 277
- Angiography-guided PCIn = 278reference
- Primary endpoint
- Target vessel failure:
- Cardiac death
- Target vessel MI
- Clinically driven target vessel revascularization
- Follow-up
- 1 year after randomization
Methodological detailsmulticentre, open-label, 24 centres in China
- Multicentre
- Open-label
- 24 centres in China
Primary result
As reported in the abstract
1 year
Hazard ratio
0.40
95% CI 0.23–0.71
P = 0.002
Events by treatment group
IVUS-guided PCIvs Angiography-guided PCI
HR 0.40 (95% CI 0.23–0.71); P = 0.002
Original publication
IVUS or Angiography Guidance for Percutaneous Coronary Intervention in Complex Coronary Bifurcation Lesions: The DKCRUSH VIII Randomized Clinical Trial. J Am Coll Cardiol. Published 30 March 2026. doi:10.
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