Does LDL-C determination method affect statin prescribing for primary prevention? A register-based study in Southern Denmark
Main finding · Statin initiationResult — go to the resultAdjusted odds ratio 1.23 95% CI 1.17–1.30Authors' conclusion
Differences in the reporting of LDL -C from laboratories using different methods have a substantial influence on physician's decisions to prescribe statins.
Study context
- Population
- Statin-naïve patients ≥40 years without CVD, diabetes or CKD with LDL-C determined 2018–2019, Region of Southern Denmark37% direct LDL-C
- Participants
- 202,807 patients
- Exposure
- Direct vs calculated LDL-C determination
- Outcome
- Statin initiation for primary prevention of CVD
Methodological detailsregister-based
- Register-based
Main finding
Statin initiation
Adjusted odds ratio
1.23
95% CI 1.17–1.30
By group
Direct LDL-Cvs Calculated LDL-C
adjusted OR 1.23 (95% CI 1.17–1.30)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted OR (95% CI) | |
|---|---|---|
| Statin initiation, triglycerides >1.7 mmol/L (subgroup) | 1.41 (1.30–1.52) | |
| 0.512Adjusted odds ratio (log scale) |
Reported LDL-C
- Reported LDL-C — In direct group, re-calculated (Friedewald) LDL-C lower than reported direct LDL-C
- 0.35 mmol/L
Original publication
Does LDL-C determination method affect statin prescribing for primary prevention? A register-based study in Southern Denmark. Eur Heart J Cardiovasc Pharmacother. Published 30 May 2024. doi:10.
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