Arrhythmias & electrophysiology
Durability of thermal pulmonary vein isolation in persistent atrial fibrillation assessed by mandated repeat invasive study
An erratum to this article was published (Heart Rhythm, Jul 2025 ↗)
Authors' conclusion
PVI durability may be poor in those with significant LA scarring and dilatation, even with modern thermal ablation technologies. RF resulted in significantly better PVI durability than did CB in this complex population.
Study context
- Population
- Patients with persistent AF and significant left atria (LA) disease38 underwent both procedures
- Participants
- 44 patients
- Comparison
- Radiofrequency (RF) vs cryoballoon (CB) pulmonary vein isolation (PVI)
- RFn = 21
- CBn = 17reference
- Primary endpoint
- PV reconnection (PVI durability) at mandated redo procedure
- Follow-up
- 2 months
Methodological detailsmandated repeat invasive study at 2 months
- Mandated repeat invasive study at 2 months
Primary result
As reported in the abstract
PV reconnection
P = 0.022
- PV reconnection overall
- 73 of 152 PVs (48.0%)
- Reconnection of at least 1 PV
- >75% of patients
Further findings
Index procedure duration
P < 0.001
Index fluoroscopy time
P < 0.001
Ablation time to reisolate PVs at redo · 2 months
P < 0.001
- LA myocardium with voltage < 0.5 mV (index RF procedure)
- 47% · median
Original publication
Durability of thermal pulmonary vein isolation in persistent atrial fibrillation assessed by mandated repeat invasive study. Heart Rhythm. Published 16 April 2024. doi:10.
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