Arrhythmias & electrophysiology
Regional conduction velocities determined by noninvasive mapping are associated with arrhythmia-free survival after atrial fibrillation ablation
Authors' conclusion
The absence of ECGi-determined slow-conduction areas well discriminates PVI responders from nonresponders.
Study context
- Population
- Patients scheduled for atrial fibrillation (AF) ablation (pulmonary vein isolation (PVI) only) and healthy controls, electrocardiographic imaging (ECGi) in sinus rhythm
- Participants
- 52 vs 19
- Exposure
- AF patients scheduled for PVI vs healthy controls; patients without vs with slow-conduction areas
- AFn = 52
- Healthy controlsn = 19reference
- Outcome
- Noninvasively (ECGi) determined regional atrial conduction velocities and their association with arrhythmia-free survival after PVI
Methodological detailsconsecutive patients, validated by invasive mapping
- Consecutive patients
- Validated by invasive mapping
Main finding
As reported in the abstract
ECGi-determined atrial conduction velocities and arrhythmia-free survival
| Group | Value | Slowest segment conduction velocity |
|---|---|---|
| AF | mean 1.45 (SD 0.15) m/s | 0.8 ± 0.22 m/s |
| Healthy controls | mean 1.64 (SD 0.15) m/s | 1.08 ± 0.26 m/s |
Value
AFmean 1.45 (SD 0.15) m/s
Healthy controlsmean 1.64 (SD 0.15) m/s
Slowest segment conduction velocity
AF0.8 ± 0.22 m/s
Healthy controls1.08 ± 0.26 m/s
- AF vs Healthy controls: P < 0.0001 — mean atrial conduction velocity
- AF vs Healthy controls: P < 0.0001 — slowest segment conduction velocity
- No slow-conduction areas vs ≥1 slow-conduction area: P = 0.002 — 12-month arrhythmia-free survival 88.9% vs 48.0%; slow-conduction area = mean conduction velocity <0.78 m/s
Observational data: associations, not effects.
Original publication
Regional conduction velocities determined by noninvasive mapping are associated with arrhythmia-free survival after atrial fibrillation ablation. Heart Rhythm. Published 16 April 2024. doi:10.
Summarised from the published abstract; every number is checked against it