Acute cardiac care & resuscitation
Duration of cardiopulmonary resuscitation and phenotype of post-cardiac arrest brain injury
Authors' conclusion
Brain injury phenotype is related to CPR duration, which is a surrogate for severity of HIBI. The sequence of most likely primary HIBI phenotype with progressively longer CPR duration is awake, coma without BSIB or edema, BSIB, and finally cerebral edema.
Study context
- Population
- Patients resuscitated from in- or out-of-hospital cardiac arrest, January 2010 to January 2020
- Participants
- 545 / 1,065 / 548 / 438
- Exposure
- Brain injury phenotypes by cardiopulmonary resuscitation (CPR) duration
- Awaken = 545
- Non-malignant coman = 1,065
- Burst suppression with identical bursts (BSIB)n = 548
- Cerebral edeman = 438
- Outcome
- Primary hypoxic ischemic brain injury (HIBI) phenotype on presentation by CPR duration
Methodological detailsprospective registry, in- and out-of-hospital cardiac arrest
- Prospective registry
- In- and out-of-hospital cardiac arrest
Main finding
As reported in the abstract
CPR duration
- Overall median CPR duration
- 16 [IQR 8-28] minutes
Observational data: associations, not effects.
Further findings
Phenotype distribution
Phenotype distribution
- Predicted probability of phenotype changes over time
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Duration of cardiopulmonary resuscitation and phenotype of post-cardiac arrest brain injury. Resuscitation. Published 8 May 2023. doi:10.
Summarised from the published abstract; every number is checked against it