Heart failure & cardiomyopathies
Dynamic Evolution of Tricuspid Regurgitation During Hospitalization in Patients with Acute Decompensated Heart Failure
Authors' conclusion
Among ADHF patients with moderate-severe TR at admission, 49% had an in-hospital improvement in TR severity, which was associated with a reduction in risk of 5-year all-cause mortality and morbidity outcomes.
Study context
- Population
- Patients admitted for acute decompensated heart failure (ADHF) with ≥2 in-hospital echocardiographic evaluations of tricuspid regurgitation (TR)318 (30%) moderate-severe TR at admission
- Participants
- 1,054 patients
- Exposure
- In-hospital TR evolution: improved TR vs persistent moderate-severe TR vs persistent trivial-mild TR
- Outcome
- Composite of:
- All-cause mortality
- HF hospitalization
- Follow-up
- 5 years
Main finding
As reported in the abstract
Hazard ratio
0.524
P = 0.008
Improved TR vs Persistent moderate-severe TR · adjusted
Hazard ratio
0.878
P = 0.575
Improved TR vs Persistent trivial-mild TR · adjusted; no different
Observational data: associations, not effects.
Further findings
TR improvement among patients with moderate-severe TR at admission · in-hospital
- Improved TR severity
- 49%
Predictors of lower probability of improved TR
- AF, previous HF and higher pre-admission loop diuretic dosage associated with lower probability of improved TR
Subgroups by in-hospital variation of mitral regurgitation
- Results consistent across all subgroups
Original publication
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