Heart failure & cardiomyopathiesRandomised controlled trial
Inferior Vena Cava Ultrasound to Guide Decongestion in Acute Decompensated Heart Failure
- Randomised controlled trial
- multicentre
Authors' conclusion
Additional ultrasound evaluation of IVC diameters did not improve decongestion treatment compared with clinical assessment alone among patients admitted for ADHF.
Study context
- Population
- Patients admitted for acute decompensated heart failure (ADHF) (NYHA class ≥III) with pulmonary congestion, peripheral edema and NT-proBNP >300 ng/L327 in primary ITT analysis
- Participants
- 388 patients
- Comparison
- Inferior vena cava (IVC) ultrasound vs Clinical assessment alone
- Primary endpoint
- Change in NT-proBNP levels
- Follow-up
- Baseline to discharge
Primary result
As reported in the abstract
Change in NT-proBNP from baseline to discharge · discharge
Between-group difference in change in NT-proBNP
5.4%, P = 0.58 (95% CI −9.4% to 22.6%)
Secondary outcomes
Secondary endpoints (incl. hemoconcentration, diuretic intensity)
- No difference between groups consistently observed; similar rates of hemoconcentration and intensity of diuretic treatment
Safety
Safety events
- Numerically less frequent in the IVC ultrasound-guided group
Original publication
Inferior Vena Cava Ultrasound to Guide Decongestion in Acute Decompensated Heart Failure. JACC Heart Fail. Published 9 September 2025. doi:10.1016/j.jchf.2025.102578
Summarised from the published abstract; every number is checked against it