Heart failure & cardiomyopathiesCohort study
Early Diagnosis of ATTR-CM by Age- and Carpal Tunnel Biopsy-Guided Screening
- prospective, multicenter cohort study
Authors' conclusion
Systematic age- and biopsy-guided screening during CTS surgery identified a high proportion of carpal amyloid deposition. Among amyloid-positive CTS patients, 1 in 6 was diagnosed with early-stage ATTR-CM. This approach demonstrated a higher yield in identifying ATTR-CM with mild disease burden and may serve as a tool for earlier diagnosis.
Study context
- Population
- Men ≥65 and women ≥75 years undergoing surgery for idiopathic carpal tunnel syndrome (CTS); control cohort of contemporary clinically diagnosed wildtype ATTR-CM patientsCTS patients included (median age 79 years [IQR: 75–82])
- Participants
- 109 men
- Exposure
- Disease severity between screening-detected and clinically diagnosed ATTR-CM patients
- Screening-detected ATTR-CMn = 9
- Clinically diagnosed patientsn = 47
Main finding
As reported in the abstract
Patients with tenosynovial amyloid deposition
61/109 patients (56.0%; 95% CI: 46.1-65.5)
Of the 61 amyloid-positive patients, completed cardiac evaluation
52/61
Observational data: associations, not effects.
Further findings
National Amyloidosis Centre stage I
ATTR-CM diagnosis among amyloid-positive patients who completed cardiac evaluation
- ATTR-CM diagnosed, of the 52 who completed cardiac evaluation
- 9/52 patients (17.3%; 95% CI: 8.2-30.3)
- Median age of those diagnosed
- 83 years [IQR: 80-84]
- Male-to-female ratio
- 3.5:1; n = 7/2
Original publication
Summarised from the published abstract; every number is checked against it