Heart failure & cardiomyopathies
Identification of Wild-Type Transthyretin Cardiac Amyloidosis in Patients with Carpal Tunnel Syndrome Surgery (CACTuS)
Authors' conclusion
The study found an ATTRwt prevalence of 8.3% in a population of age and gender-selected patients with a recent history of CTS. The identified patients with ATTRwt had less structural and functional cardiac involvement than clinical ATTRwt controls.
Study context
- Population
- Patients aged ≥60 years at the time of carpal tunnel syndrome (CTS) surgerymean age 74.5 years, 90% male
- Participants
- 120 patients
- Exposure
- Screen-detected ATTRwt vs clinical ATTRwt controls
- Screened ATTRwtn = 10
- Clinical ATTRwtn = 51reference
- Outcome
- ATTRwt prevalence on red-flag screening
Methodological detailsmatched comparison with clinical ATTRwt controls
- Matched comparison with clinical ATTRwt controls
Main finding
As reported in the abstract
ATTRwt prevalence
Suspicion of ATTR raised
67
55.8%
Diagnosed with ATTRwt
10
8.3%
Observational data: associations, not effects.
Further findings
Disease severity, screened vs clinical ATTRwt
- Screened ATTRwt predominantly asymptomatic, mildly elevated NT-proBNP, mildly increased left ventricular hypertrophy (LVH), preserved LVEF and systolic longitudinal function; differed significantly from clinical ATTRwt controls
- P < 0.001
Original publication
Identification of Wild-Type Transthyretin Cardiac Amyloidosis in Patients with Carpal Tunnel Syndrome Surgery (CACTuS). ESC Heart Fail. Published 3 October 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →