Early vascular responses to abluminal biodegradable polymer-coated versus circumferential durable polymer-coated newer-generation drug-eluting stents in humans: a pathological study
Authors' conclusion
Single-layered endothelial coverage begins in the days after newer-generation DES placement, and BP-DES potentially exhibit faster strut coverage with smooth muscle cell infiltration than DP-DES in humans. Nevertheless, vessel healing remains suboptimal in both stents at 30 days.
Study context
- Population
- Human autopsy cases with newer-generation drug-eluting stent (DES) implanted for <90 days
- Participants
- 38 coronary lesions
- Comparison
- Abluminal biodegradable polymer-coated DES vs circumferential durable polymer-coated DES
- BP-DESn = 14
- DP-DESn = 24reference
- Outcome
- Degree of strut coverage (grade 0 bare to grade 3 endothelium with underlying smooth muscle cell layers)
Methodological detailsautopsy, human autopsy cases
- Autopsy
- Human autopsy cases
Main finding
As reported in the abstract
Strut coverage (multilevel mixed-effects ordered logistic regression)
BP-DES vs DP-DESOdds ratio (95% CI)P value
Greater strut coverage with BP-DES
3.64(1.37–9.67)
P = 0.009Adjusted for duration following implantation and underlying tissue characteristics
2.74(1.10–6.80)
P = 0.030Further findings
Predictive probability of grade 2 and 3 coverage · 30 days
Predictive probability of grade 2 and 3 coverage · 90 days
Duration following implantation
Duration following implantation
- Similar in DP- and BP-DES
Earliest focal grade 2 coverage
- Observed as early as 5 days after implantation in both stents
Inflammation and fibrin deposition
- Low inflammation and similar degree of fibrin deposition in both stents
Original publication
Early vascular responses to abluminal biodegradable polymer-coated versus circumferential durable polymer-coated newer-generation drug-eluting stents in humans: a pathological study. EuroIntervention. Published 20 March 2023. doi:10.
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