Heart failure & cardiomyopathies
Echocardiographic Characterization of Myocardial Stiffness in Healthy Volunteers, Cardiac Amyloidosis, and Hypertrophic Cardiomyopathy: A Case-Control Study Using Multimodality Imaging
Authors' conclusion
Intrinsic cardiac elastography is a reliable noninvasive tool to measure myocardial stiffness. In this pilot study, it is related to imaging markers of interstitial expansion and amyloid burden.
Study context
- Population
- Healthy volunteers and patients with cardiac amyloidosis or hypertrophic cardiomyopathyparticipants in whom myocardial stiffness was estimated
- Participants
- 54 volunteers
- Exposure
- Myocardial stiffness using intrinsic cardiac elastography in healthy volunteers versus those with myocardial diseases (ie, cardiac amyloidosis [CA] and hypertrophic cardiomyopathy)
- CA cohortn = 28
- Hypertrophic cardiomyopathy cohortn = 10
- Healthy volunteersn = 16
- Outcome
- Myocardial stiffness (iVP)
Main finding
As reported in the abstract
P = 0.011
Observational data: associations, not effects.
Further findings
Correlation of iVP in patients with CA or hypertrophic cardiomyopathy
- NT-proBNP
- ρ=0.498, P =0.003
- Extracellular volume
- ρ=0.646, P =0.004
- Cardiac amyloid activity
- ρ=0.891, P <0.001
Multivariate linear regression
- Extracellular volume was independently associated with myocardial stiffness even after accounting for indexed left ventricular mass, global longitudinal strain, and E/e’
Upper limit of normal of iVP in healthy volunteers
- Upper limit of normal of iVP
- 1.7 m/s
Patients with CA and normal myocardial stiffness (iVP <1.7 m/s)
- Lower NT-proBNP
- P = 0.034
- Lower troponin T
- P = 0.041
- Lower National Amyloidosis Center stage
- P = 0.031
- Smaller interstitial expansion
- P = 0.014
- Smaller amyloid burden
- P = 0.056
Original publication
Echocardiographic Characterization of Myocardial Stiffness in Healthy Volunteers, Cardiac Amyloidosis, and Hypertrophic Cardiomyopathy: A Case-Control Study Using Multimodality Imaging. Circ Cardiovasc Imaging. Published 3 March 2025. doi:10.
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