Heart failure & cardiomyopathies
Towards non-invasive assessment of myocardial work using myocardial stiffness and strain: a human pilot study
Authors' conclusion
Calculating segmental myocardial work based on myocardial stiffness and strain measurements is technically feasible. This approach overcomes the inherent limitations of current methods by introducing a direct quantitative measure of myocardial stress.
Study context
- Population
- Children with hypertrophic cardiomyopathy, aortic stenosis, and healthy volunteers; myocardial work assessed in the basal antero-septal segment by shear wave elastography and strainsubjects included per group
- Comparison
- One-beat segmental work, the stress-strain loop area, and contributive and dissipative work were compared between groups.
- Healthy volunteers (HV)n = Twenty
- Hypertrophic cardiomyopathy (HCM)n = 20
- Aortic stenosis (AS)n = 5
- Outcome
- Age
Main finding
As reported in the abstract
Further findings
One-beat segmental work — AS vs HV · significantly higher in AS
P = 0.02
Stress-strain loop area — AS and HV vs HCM · higher in AS and HV than in HCM
P < 0.01
| Outcome | P value |
|---|---|
| One-beat segmental workHCM vs HV · lower in HCM | P = 0.01 |
- Desynchronized work in HCM
- 17.3 ± 28.9 µJ/mm · dissipative work during systole · contributive work during diastole 15.3 ± 18.0 µJ/mm
Desynchronized work in HCM
- Desynchronized work was prevailing in HCM
Original publication
Towards non-invasive assessment of myocardial work using myocardial stiffness and strain: a human pilot study. Eur Heart J Cardiovasc Imaging. Published 14 March 2025. doi:10.
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