Pulmonary vascular disease & thromboembolism
Echocardiographic right-ventricular global wasted work predicts haemodynamics and risk profile in pulmonary arterial hypertension
Authors' conclusion
RVGWW correlated well with invasive haemodynamic parameters and was found to predict a worse haemodynamic and high-risk profile in a prospective cohort of PAH patients.
Study context
- Population
- Patients with pulmonary arterial hypertension (PAH) confirmed by right heart catheterization (RHC) (58 ± 14 years old, 72% female)
- Participants
- 58 patients
- Exposure
- RV myocardial work indices vs RHC haemodynamics and guideline risk profile
- Outcome
- Association of right ventricular myocardial work (RVMW) indices with RHC haemodynamics (mPAP, PVR, SVI, PAC) and high mortality risk profile
Main finding
As reported in the abstract
RV global wasted work (RVGWW) correlation with mean pulmonary artery pressure (mPAP)
R = 0.46
P < 0.001
RVGWW correlation with pulmonary vascular resistance (PVR)
R = 0.51
P < 0.001
RVGWW correlation with stroke volume index (SVI)
R = −0.3
P = 0.024
RVGWW correlation with pulmonary arterial compliance (PAC)
R = −0.31
P = 0.02
Observational data: associations, not effects.
Original publication
Echocardiographic right-ventricular global wasted work predicts haemodynamics and risk profile in pulmonary arterial hypertension. Eur Heart J Cardiovasc Imaging. Published 16 September 2025. doi:10.
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