Arrhythmias & electrophysiology

Education of healthcare professionals to improve guideline adherence in atrial fibrillation: the STEEER-AF cluster-randomized clinical trial

Nat MedPublished Cluster randomised controlled trial

Authors' conclusion

Thus, while the education of healthcare professionals improved substantial gaps in implementation for rhythm control, it had no significant effect on stroke prevention.

Study context

Population
Patients with atrial fibrillation (AF) seen in routine practice
Participants
1,732 patients70 centres
Comparison
Education of healthcare professionals vs standard practice
Primary endpoint
Co-primary: guideline adherence (ESC class I and III recommendations) on stroke prevention and on rhythm control
Follow-up
6-9-months follow-up
Methodological details70 centres in six countries
  • 70 centres in six countries

Primary result

As reported in the abstract

Guideline adherence

Intervention

Stroke prevention
67.5%
Rhythm control
33.9%

Control

Stroke prevention
60.9%
Rhythm control
22.9%

Stroke prevention

Intervention67.5%
Control60.9%

Rhythm control

Intervention33.9%
Control22.9%
Intervention vs ControlAdjusted relative risk (95% CI)P value
Stroke prevention
1.10(0.97–1.24)
P = 0.13
Rhythm control
1.51(1.04–2.18)
P = 0.03

Secondary outcomes

OutcomeImprovement (%) (95% CI)P value
Patient-reported integrated AF management5.1 (1.4%–8.9%)P = 0.01

Original publication

Education of healthcare professionals to improve guideline adherence in atrial fibrillation: the STEEER-AF cluster-randomized clinical trial. Nat Med. Published 13 June 2025. doi:10.1038/s41591-025-03751-2

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